SandboxAQ Supercharges OpenFold3 with AQAffinity for Structure-Free Drug Potency Prediction

SandboxAQ launched AQAffinity, an AI model built on the OpenFold Consortium's OpenFold3 that predicts binding affinity, how strongly a drug candidate attaches to its target protein, directly from a protein's sequence without needing an experimentally determined 3D structure first. SandboxAQ says the model runs roughly 1,000 times faster than free-energy perturbation, a standard but computationally expensive method for estimating binding strength. AQAffinity is available on Hugging Face under an Apache 2.0 open-source license. SandboxAQ is a Parkway Venture Capital portfolio company.

Read the full article: SandboxAQ's AQAffinity announcement